eISSN: 2345-4202  
J Nephropharmacol. 2017;6(2):33-37.

Review

Proton-pump inhibitors and risk of renal disease

Mahrang Hedaiaty 1, Mohammad Reza Tamadon 2, Armin Amiri 3, Leila Mahmoodnia 4 *

1 Fatemieh Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
2 Department of Internal Medicine, Semnan University of Medical Sciences, Semnan, Iran
3 School of Pharmacy, Utrecht University, Utrecht, The Netherlands
4 Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding author: Leila Mahmoodni, Email: leilamahmoodnia@yahoo.com

Abstract

Proton pump inhibitors (PPIs) are one group of drugs that inhibit gastric acid secretion by binding irreversibly to the gastric proton pump to the gastric proton pump. This paper aimed to review the impact of PPIs on kidney function and structure by presenting the updated information in this regard. In this review, we summarize in electronic databases including Google Scholar, EMBASE, MEDLINE, Scopus and EBSCO during the period of 1980 to 2017 by using the following search terms; proton-pump inhibitors, kidney injury, renal diseases, adverse events of proton-pump inhibitors, acute interstitial nephritis, renal injury and chronic kidney disease. The PPIs are known as one group of drugs that well-tolerated in healthy subjects and serious harms are rare. There are reports associated with adverse effects of PPIs administration in long-term such as; increasing the incident risk of kidney injury, hyper-secretion of gastric acid after their withdrawal, bone fracture, decreased levels of blood magnesium, interaction with metabolism of antiplatelet agents, increased risk of enteric infections and community-acquired pneumonia.
Implication for health policy/practice/research/medical education:
This paper aimed to review the impact of proton pump inhibitors (PPIs) on kidney function and structure by presenting the updated information in this regard. The adverse effects of PPIs administration include an increase in the incident risk of kidney injury, hyper-secretion of gastric acid after their withdrawal, bone fracture, decreased levels of blood magnesium, interaction with metabolism of antiplatelet agents, increased risk of enteric infections and community-acquired pneumonia.
Please cite this paper as: Hedaiaty M, Tamadon MR, Amiri A, Mahmoodnia L. Proton-pump inhibitors and risk of renal disease. J Nephropharmacol. 2017;6(2):33-37. DOI: 10.15171/npj.2017.02
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Submitted: 20 Dec 2016

Accepted: 03 Feb 2017
First published online: 10 Feb 2017
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