Implication for health policy/practice/research/medical education:
Polycystic kidney disease (PKD) is characterized by the growth of numerous fluid filled cysts in the kidneys. PKD cysts can profoundly enlarge the kidneys while replacing much of the normal structure, resulting in reduced renal function and leading to end-stage renal disease (ESRD). Given that currently, there are no active effective treatments for PKD, other than renal replacement therapy when indicated, the focus of scientists and clinicians ought for the development of therapies to slowdown disease progression. This review focuses on the current understanding of the pathways and therapeutic targets in PKD.
Please cite this paper as: Bhaskar LVKS, Elumalai R, Periasamy S. Pathways, perspectives and pursuits in polycystic kidney disease. J Nephropharmacol. 2016;5(1):41-48.