eISSN: 2345-4202  
J Nephropharmacol. 2016;5(2):80-85.
PMID: 28197508
PMCID: PMC5297571

Original

Impacts of Hibiscus esculentus extract on glucose and lipid profile of diabetic rats

Fatemeh Akbari 1, Najmeh Shahinfard 1, Mahmoud Mirhoseini 1, Hedayatollah Shirzad 1, Esfandiar Heidarian 2, Shabnam Hajian 3, Mahmoud Rafieian-Kopaei 1 *

1 Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran
2 Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran
3 Nickan Research Institute, Isfahan, Iran
*Corresponding author: Prof. Mahmoud Rafieian-Kopaei, Email: rafieian@yahoo.com

Abstract

Introduction: Hibiscus esculentus is capable to produce various molecules including phenolic and flavonoid compounds, phytosteroids with antioxidant property. Therefore, it has the potential to show antidiabetic activities.

Objectives: This study was aimed to evaluate the impacts of Hibiscus esculentus extract on glucose and lipid profile of diabetic rats. The flavonoid, flavonol and phenolic components, as well as antioxidant activity of Hibiscus esculentus was also evaluated.

Materials and Methods: In a preclinical study, 40 male Wistar rats were designated into four 10-member groups, i.e., control, diabetic control, diabetic Hibiscus esculentus, and diabetic glibenclamide. The Alloxan-induced diabetic rats received extracts orally for four weeks. Then, the serum biochemical factors were measured and compared by analysis of variance (ANOVA).

Results: Serum glucose, triglyceride (TG), cholesterol, and low density lipoprotein cholesterol (LDL-C) were significantly decreased and high density lipoprotein cholesterol (HDL-C) increased in diabetic Hibiscus esculentus rats compared to diabetic control ones (P < 0.05).

Conclusion: Improving the blood glucose and lipid profile in diabetic rats indicates that Hibiscus esculentus extract might be beneficial in diabetic patients.

Implication for health policy/practice/research/medical education:

Diabetes mellitus is one of the most widespread endocrine diseases. Considering that herbs are not without complications, due to the easy access, less side effects and toxicity, as well as proper cost are worthy of attention as suitable alternatives of synthetic drugs. Hibiscus esculentus plant is a rich source of bioactive molecules such as phenolic compounds, triterpenes and phytosterols with anti-oxidant activities. Therefor it is expected to be effective in improving glucose and lipid profile diabetes mellitus.

Please cite this paper as: Akbari F, Shahinfard N, Mirhoseini M, Shirzad H, Heidarian E, Hajian S, Rafieian-Kopaei M. Impacts of Hibiscus esculentus extract on glucose and lipid profile of diabetic rats. J Nephropharmacol. 2016; 5(​2):80-85.

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