eISSN: 2345-4202  
J Nephropharmacol. 2016;5(2):91-97.
PMID: 28197510
PMCID: PMC5297573

Original

A study of primary glomerular diseases in adults; clinical, histopathological and immunofluorescence correlations

Ananta Satya Narayana Modugumudi 1, Phaneendra Bobbidi Venkata 1, Siva Kumar Vishnu Bottla 2, Radhika Kottu 1 * , Rukmangadha Nandyala 1, Rashmi Patnayak 1, Amit Kumar Chowhan 1, Lakshmi Amancharla Yadgiri 3

1 Department of Pathology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India
2 Department of Nephrology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India
3 Department of Radiology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India
*Corresponding author: Amit Kumar Chowhan, Email: chowhanpath@gmail.com

Abstract

Introduction: The frequency of primary glomerular diseases is variable from one part of the world to the other. Data published from India has shown wide range of variation in the different regions of the country.

Objectives: This study reports the frequency of primary glomerulonephritis (GN) in adults in the Rayalaseema region of south India.

Materials and Methods: The study is based on prospective evaluation of renal biopsies done during 2 years 4 months period (May 2010-August 2012). A total of 137 cases of primary GN were studied by light microscopy and immunofluorescence (IF). The patients age range between 15-74 years.

Results: Most frequent primary GN was membranous nephropathy (MN) constituting 35.8%, followed by minimal change disease (MCD) at 16.7%.

Conclusion: This study demonstrates that MN is the most common primary GN encountered in the adults, the second more frequent is MCD. This result is in contrast to previous reports from India where IgA nephropathy (IgAN) and MCD were reported as the most common primary GN in whole population.

Implication for health policy/practice/research/medical education:

To determine the frequency of primary glomerulonephritis (GN) in adults in the Rayalaseema region of South India, we conducted a prospective study in 137 cases of primary GN diagnosed by light microscopy and immunofluorescence (IF) on renal biopsies. We found nephrotic syndrome (NS) was the most common clinical presentation followed by rapidly progressive renal failure (RPRF) and membranous nephropathy (MN) was the most common primary renal disease followed by minimal change disease (MCD), which was in contrast to previous reports from India where IgA nephropathy (IgAN) and MCD were reported as the most common primary glomerulonephritis (PGN) in whole population. There is a need for the establishment of the registry on glomerular diseases.

Please cite this paper as: Modugumudi ASN, Venkata PB, Bottla SKV, Kottu R, Nandyala R, Patnayak R, et al. A study of primary glomerular diseases in adults; clinical, histopathological and immunofluorescence correlations. J Nephropharmacol. 2016; 5(​2):91-97.

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