eISSN: 2345-4202  
J Nephropharmacol. 2018;7(1):10-17.
doi:10.15171/npj.2018.04

Review

Efficacy and adverse effects of cidofovir for treatment of BK virus infection in kidney transplant recipients

Supavit Chesdacha 1,2, Charat Thongprayoon 3, Jackrapong Bruminhent 2, Wisit Cheungpasitporn 4,5 *

1 Department of Medicine, University of Minnesota, Minnesota, USA
2 Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Thailand
3 Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USA
4 Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA
5 Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Mississippi, USA
*Corresponding author: Wisit Cheungpasitporn, MD; Email: Email: wcheungpasitporn@gmail.com

Abstract

Kidney transplant provides patients with end-stage kidney disease a clear survival benefit compared to patients who remain on dialysis. Immunosuppressive therapy is crucial for maintaining graft survival. However, high level of suppression can increase the susceptibility for BK virus reactivation following transplantation, leading to BK virus-associated nephropathy (BK-VAN) and allograft loss. Its clinical presentations are often asymptomatic or solely rising of serum creatinine. While reduction of immunosuppression remains the mainstay treatment of BK viremia/nephropathy, there have been many proposed adjuvant therapy such as antiviral agents, fluoroquinolone, immunoglobulin, and immunotherapy. Cidofovir is one of the adjuvant therapies that have been studied in many case series and cohort studies with unclear data on benefit-risk assessment. This review aims to present the current literature on the efficacy, potential adverse effects and cost-effectiveness of cidofovir treatment for BK viremia/nephropathy.

Implication for health policy/practice/research/medical education:

This review aims to present the evidence of benefit-risk assessment of cidofovir treatment for BK virus infection in kidney transplant recipients. In this review, we discussed the efficacy and adverse side effects, which help physicians in the clinical judgment for the use of cidofovir addition to a reduction of immunosuppressant. Moreover, this review also provides brief review of current view in BK virus burden, clinical manifestation, diagnosis and other treatment methods which can be beneficial in clinical practice and future research.

Please cite this paper as: Chesdachai S, Thongprayoon C, Bruminhent J, Cheungpasitporn W. Efficacy and adverse effects of cidofovir for treatment of BK virus infection in kidney transplant recipients. J Nephropharmacol. 2018;7(1):10-17. DOI: 10.15171/ npj.2018.04. 

 

 

 

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Submitted: 19 May 2018

Accepted: 27 Aug 2017
First published online: 19 Sep 2017
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