eISSN: 2345-4202  
J Nephropharmacol. 2019;8(1):6-6.
doi:10.15171/npj.2019.06

Original

The relationship between dyslipidemia and disease activity in Iranian population with systemic lupus erythematosus 

Sepideh Hajian 1, Mohammad Ali Hosseini 2,3 * , Mohadaseh Ameri 4, Sara Khosraviani 2, Farnaz Tavasoli 2, Mohammad Ehsan Bayatpoor 5

1 Department of Nephrology, Velayat Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
2 Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran
3 Infertility and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Shahid Beheshti University of Medical Sciences, Tehran, Iran
5 Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran
*Corresponding author: Mohammad Ali Hosseini, Email: Email: smahoseini@gmail.com

Abstract

Introduction: In spite of the high prevalence of dyslipidemia in systemic lupus erythematosus (SLE) and its role in patients’ cardiovascular and kidney diseases, few studies had been conducted in this regard.

Objectives: We aimed to study the relation between dyslipidemia and disease activity in SLE patients in Iran.

Patients and Methods: This analytical cross-sectional study was conducted on SLE patients. The activity of disease was determined by SLE disease activity index (SLEDAI). The serum level of triglyceride (TG), cholesterol, low-density lipoprotein (LDL-C), and high-density lipoprotein (HDL-C) were measured. The correlation between dyslipidemia and SLE disease activity was assessed.

Results: Around 62 out of 71 patients (87%) were female (mean age was 34 years). The mean disease duration was 1 year. Around 49% of patients had active disease (SLEDAI ≥6). Proteinuria and nephritis were observed in 18% and 24%, respectively. About 62% of patients had at least one abnormality in their lipid profile. High cholesterol (>200 mg/dL), high TG (>150 md/dL), high LDL-C (>130 mg/dL) and low HDL-C (<50 mg/dL in females and <40 md/dL in males) levels were observed in 25%, 42%, 20% and 49% of patients, respectively. Patients with active disease had lower age and shorter disease duration in comparison to the others (P<0.05). There were no differences in gender and weight between patients in active and inactive phases (P>0.05). Patients with active disease had higher serum cholesterol, TG and LDL-C levels and lower levels of serum HDL-C.

Conclusion: It seems that there is a relationship between disease activity and lipid profile abnormalities in SLE patients.

Implication for health policy/practice/research/medical education:

In a study on 71 SLE patients, we concluded that dyslipidemia is commonly present in SLE patients in the Iranian population. SLE patients with active disease have higher levels of cholesterol, TG, LDL-C and lower range of HDL-C than patients with inactive disease.

Please cite this paper as: B. The relationship between dyslipidemia and disease activity in Iranian population with systemic lupus erythematosus. J Nephropharmacol. 2019;8(1):e06. DOI: 10.15171/npj.2019.06

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Submitted: 06 Aug 2018

Accepted: 18 Oct 2018
First published online: 02 Nov 2018
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