Submitted: 17 Mar 2019
Accepted: 04 May 2019
First published online: 23 May 2019
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J Nephropharmacol. 2019;8(2): e17.
doi: 10.15171/npj.2019.17
  Abstract View: 293
  PDF Download: 404


Catheter related blood stream infections; the incidence and risk factors in Iranian hemodialysis patients 

Amirhesam Alirezaei 1 * ORCID logo, Nilofar Massoudi 2, Elham Zare 3, Yasser Nouri 3

1 Urology and Nephrology Research Center, Shahid Modarres Hospital, Shahid-Beheshti University of Medical Sciences, Tehran, Iran
2 Critical Care Quality Improvement Research Center at Shahid Modarres Hospital, Department of Anaesthesiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Department of Internal Medicine, Shahid-Beheshti University of Medical Sciences, Tehran, Iran
*Corresponding author: Amirhesam alirezaei, Email: amirhesam124@gmail.com and Email: Aalirezaei@sbmu.ac.ir


Introduction: Patients with end-stage renal disease (ESRD) are routinely managed by hemodialysis. The catheter-related blood stream infections (CRBSIs) are important complications with high risk of mortality and morbidity in patients undergoing hemodialysis.

Objectives: To determine the incidence of CRBSIs in patients undergoing hemodialysis in a single center in Iran.

Patients and Methods: In this cross-sectional study, we evaluated the incidence of CRBSIs in 50 hemodialysis patients hospitalized at the Shahid-Modarres hospital of Tehran from March 2017 until March 2018. The data was collected from patients’ medical archives. The CRBSI was established by blood culture. Results: Of 50 hemodialysis patients enrolled in the study, 27 were males (54%). The mean age was 49.7 ±11. 8 years old. Positive blood culture was observed in 64% of patients. The most common causative organism was coagulase-negative staphylococci (24%). The most common comorbidity and systemic clinical symptom included hypertension (84%) and fever (92%) respectively. In most patients (74%), the length of catheter indwelling was less than one year. Echocardiography showed that 24% of the patients had vegetation.

Conclusion: The coagulase-negative staphylococci were the most frequent organisms responsible for CRBSIs among hemodialysis patients. These findings might be helpful in early diagnosis and choose the best antibiotics for treatment.

Keywords: Hemodialysis, Renal failure, Catheter-related infections, Staphylococcus, Renal failure, End-stage renal disease

Implication for health policy/practice/research/medical education:

To provide a guide on the timely use of appropriate antibiotics, we evaluated the incidence and risk factors of CRBSIs, as well as common causative microorganisms in hemodialysis patients. Based on our results coagulase-negative staphylococci are the most frequent organisms associated with CRBSI among hemodialysis patients in our hospital.

Please cite this paper as: Alirezaei AH, Massoudi N, Zare E, Nouri Y. Catheter related blood stream infections; the incidence and risk factors in Iranian hemodialysis patients. J Nephropharmacol. 2019;8(2):e17. DOI: 10.15171/npj.2019.17

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