Context: The role of N-terminal pro-B-type natriuretic peptide (NT pro-BNP) has been
understood as an important and critical biomarker in the diagnosis and predicting poor
outcome of cardiac dysfunction.
Objectives: We aimed to systematically review the papers on the value of NT pro-BNP in
prediction of sudden cardiac death (SCD) in chronic heart failure (CHF) patients.
Data Sources: This study was based on the Systematic Reviews and Meta-analysis (PRISMA)
study reporting system.
Study Selection: During the deep searches using the keywords, 67 studies were initially
considered for primary assessment. Of those, 12 were completely matched with the study
endpoint. In final, six were excluded because of unavailability of full texts or acquired data
and thus six studies were finally analyzed.
Data Extraction: Two researchers independently used the key words "chronic heart failure,
B-type natriuretic peptide, sudden cardiac death" and their combination and searched the
national and international databases including Scopus, PubMed, Science Direct, Web of
Science, Springer, and the Google Scholar search engine.
Results: The pooled prevalence of SCD in CHF patients was found to be 6.9% (95% CI: 5.2% to
9.0%). The statistical heterogeneity was high with an I2
of 84.488. Abnormal elevated level of
NT pro-BNP was significantly associated with the increased risk for SCD with a hazard ratio
of 4.2 (95% CI: 2.2 to 8.7).
Conclusion: Measuring the serum level of NT pro-BNP in CHF patients can be valuable to
predict long-term SCD. In this regard, significant elevation of this biomarker may be associated
with the four-fold risk of SCD in such patients.