Logo-npj
ePublished: 01 Jul 2012
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

J Nephropharmacol. 2012;1(2): 13-14.
  Abstract View: 1366
  PDF Download: 1207

Editorial

Hyperuricemia; a new look at an old problem

Saeed Mardani 1, Hamid Nasri 2, Mahmoud Rafieian-Kopaei 3 * , Seyed Seifollah Beladi Mousavi 4

1 Department of Nephrology, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran
3 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
4 Department of Internal Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
*Corresponding author: Prof. Mahmoud Rafieian-Kopaei, Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran. rafieian@yahoo.com
Keywords: Hyperuricemia, Diabetic nephropathy, IgA nephropathy

Implication for health policy/practice/research/medical education

Studies have shown that elevated uric acid levels have a deleterious effect, directing to endothelial dysfunction, inflammation, and vascular disease. Elevated uric acid initiates endothelial dysfunction by inhibiting nitric oxide synthetase, activating the renin-angiotensin system and causing pro-inflammation with leads to endothelial dysfunction, vascular smooth muscle cell dysfunction, and finally contributing to atherosclerosis and vascular dysfunction and aggravation of diabetic kidney disease and IgA nephropathy and other nephropathies. While various clinical investigations have shown that, lowering uric acid with allopurinol improved endothelial dysfunction in both hyperuricemic subjects and hypertensive type 2 diabetic patients with normal uric acid levels. We therefore suggest, further clinical studies, to better find the allopurinol kidney protective properties in diabetes, IgA nephropathy or other nephropathies.

Please cite this paper as: Mardani S, Nasri H, Rafieian-Kopaei M, Beladi Mousavi SS. Hyperuricemia; a new look at an old problem. J Nephropharmacol 2012; 1(2): 13-14.

First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 1366

Your browser does not support the canvas element.


PDF Download: 1207

Your browser does not support the canvas element.