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ePublished: 01 Jul 2012
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J Nephropharmacol. 2012;1(2): 19-21.
  Abstract View: 1736
  PDF Download: 1114

Original

Association of serum leptin with serum C-reactive protein in hemodialysis patients

Ebrahim Rastegari 1, Hamid Nasri 1 *

1 Section of Hemodialysis, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding author: Prof. Hamid Nasri, Department of Internal Medicine, Shahrekord University of Medical Sciences, Iran. hamidnasri@ yahoo.com

Abstract

Introduction: Recent investigations have shown that leptin is cleared principally by the kidney.

Objectives: To examine whether and how in patients on hemodialysis the level of C-reactive protein level correlate with serum leptin.

Patients and Methods: The total patients were 36. The mean patients’ age were 46 (16) years. The median length of the time patients were on hemodialysis were 19 months.

Results: The mean serum C-reactive protein was 8.7 (6.6) mg/l (median: 8 mg/l). The mean serum leptin was 9.4 (14) ng/ml (median: 5.75 ng/ml). In this study we found a significant inverse correlation of serum leptin with serum C-reactive protein (r= -0.57, p= 0.041) was seen.

Conclusion: Our data supports, the positive effect of leptin on nutrition and support the theory of protective effects (reverse epidemiology) of leptin in hemodialysis patients.

Keywords: Hemodialysis, End-stage renal failure, Leptin, C-reactive protein

Implication for health policy/practice/research/medical education:

In a study on 36 stable hemodialysis patients, we found, the inverse correction of leptin with C-reactive protein level. Our data supports, the positive effect of leptin on nutrition and support the theory of protective effects (reverse epidemiology) of leptin in hemodialysis patients.

Please cite this paper as: Rastegari E, Nasri H. Association of serum leptin with serum C-reactive protein in hemodialysis patients. J Nephropharmacol 2012; 1(2): 19-21.

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