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ePublished: 01 Jul 2014
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J Nephropharmacol. 2014;3(2): 33-37.
  Abstract View: 1370
  PDF Download: 1240

Original

Pathological patterns of mesangioproliferative glomerulonephritis seen at a tertiary care center

Ghadeer A. Mokhtar 1 * , Sawsan Jalalah 1, Shabnum Sultana 1

1 Department of Pathology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
*Corresponding author: Ghadeer A. Mokhtar; Department of Pathology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. ghadeer200@hotmail.com

Abstract

Background: Mesangioproliferative glomerulonephritis (MesPGN) is a common morphological pattern that encompasses several groups of renal diseases including IgA nephropathy (IgAN), IgM nephropathy (IgMN), lupus nephritis (LN), C1q nephropathy (C1qN) and other entities.

Objectives: The aim of this study was to analyze the pathological findings and the clinical features of cases of MesPGN seen at the king Abdulaziz University, in Saudi Arabia.

Patients and Methods: A total of 750 percutaneous native renal biopsies were seen at our institution from January 2000 to December 2011. All the cases diagnosed as MesPGN on light microscopy (LM) were retrieved from the archives of pathology. The pathological features and the clinical data of these cases were reviewed. The clinical data was available for 80 cases only.

Results: A total of 103 cases (14%) met the inclusion criteria for the diagnosis of MesPGN. The most common diagnostic entity was IgMN (46.6%) followed by IgAN (30%) along with few cases of class II LN, C1qN, minimal change disease (MCD), Alport’s syndrome, focal segmental glomerulosclerosis (FSGS), thin basement membrane disease (TBMD), and fibrillary glomerulonephritis. The most common clinical presentation was nephrotic syndrome seen in 71% of 80 cases, followed by hematuria (14%). Histologically, focal mesangial proliferation was seen in 62% while diffuse proliferation was seen in 38% of the cases.

Conclusion: Mesangioproliferative glomerulonephritis is an important cause of nephrotic syndrome in young adults in the western region of Saudi Arabia. Future studies from the region are needed to elucidate the clinical relevance of mesangial cell proliferation to the end stage kidney diseases.

Keywords: Mesangioproliferative glomerulonephritis, IgM nephropathy, IgA nephropathy

Implication for health policy/practice/research/medical education:

Mesangioproliferative glomerulonephritis is an important cause of nephrotic syndrome in young adults in the western region of Saudi Arabia. Future studies from the region are needed to elucidate the clinical relevance of mesangial cell proliferation to the end stage kidney diseases.

Please cite this paper as: Mokhtar GA, Jalalah S, Sultana S. Pathological patterns of mesangioproliferative glomerulonephritis seen at a tertiary care center. J Nephropharmacol 2014; 3(2): 33-37.

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