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J Nephropharmacol. 2017;6(1): 9-12.
PMID: 28197521
PMCID: PMC5295657
  Abstract View: 1743
  PDF Download: 1225

Original

Impact of Kelussia odoratissima Mozaffarian lipid profile and fasting blood sugar in hyperlipidemia patients

Marzieh Kafeshani 1, Mahmoud Mirhosseini 2, Ali Momeni 2, Rahmatollah Rabiei 2, Mahmoud Rafieian-Kopaei 2 *

1 Nutrition and Food Science School, Isfahan University of Medical of Sciences, Isfahan, Iran
2 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding author: Prof. Mahmoud Rafieian-Kopaei, rafieian@yahoo.com

Abstract

Introduction: Hyperlipidemia is associated with increased risk of cardiovascular disease. Each type of medication works differently and has different types of side effects. Flavonoids are a group of polyphenolic compounds with antioxidant properties that help reducing the cardiovascular risk factors. Kelussia odoratissima is a flavonoid containing plant.

Objectives: The aim of this study was investigating the effect of this herb on lipid and glucose profile in hyperlipidemia patients.Patients and Methods: This study performed on 61 hyperlipidemia patients. They assigned in control and intervention groups. The control group received 40 mg/day of lovastatin and intervention group received 40 mg/day of Lovastatin plus 2 g/day powder of Kelussia odoratissima. Before, two weeks and 1 month after the beginning of the study, cholesterol, triglyceride (TG), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), high density lipoprotein cholesterol (HDL-C), and fasting blood sugar (FBS) were measured. Data were analyzed by variance analysis with repeated measures, chi-square and t tests.

Results: The reduction rate of cholesterol, TG, VLDL-C and LDL-C was similar in the control and intervention groups. The HDL-C rate was higher in intervention group compared to control group (P < 0.05). The mean LDL/HDL ratio decreased during the study (P < 0.001); however, there was not any significant difference between the two groups (P > 0.05). The mean of FBS did not change between and within groups (P > 0.05).

Conclusion: Kelussia odoratissima did not have a desirable effect on serum lipid profile and FBS in hyperlipidemic patients that use lovastatin, but is able to increase HDL-C significantly

Keywords: Hyperlipidemia, Human, Kelussia odoratissima, Triglyceride, Cholesterol

Implication for health policy/practice/research/medical education:

In a study on 61 hyperlipidemia patients who were treated with 40 mg/day of lovastatin plus 2 g/day powder of Kelussia odoratissima, this herb did not have a desirable effect on serum lipid profile and fasting blood sugar (FBS) in hyperlipidemic patients, however, this herb had the capability to increase high density lipoprotein cholesterol (HDL-C) significantly.

Please cite this paper as: Kafeshani M, Mirhosseini M, Momeni A, Rabiei R, Rafieian-Kopaei M. Impact of Kelussia odoratissima Mozaffarian lipid profile and fasting blood sugar in hyperlipidemia patients. J Nephropharmacol. 2017; 6(1):9-12.

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