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Submitted: 19 Mar 2020
Accepted: 03 Jul 2020
ePublished: 24 Jul 2020
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J Nephropharmacol. 2021;10(1): e08.
doi: 10.34172/npj.2021.08
  Abstract View: 377
  PDF Download: 138

Original

Glucoherb versus metformin on glycemic markers and glycosylated hemoglobin in prediabetes patients; a clinical trial study

Iman Izadi 1 ORCID logo, Rahil Riahi Samani 1 * ORCID logo, Afsaneh Malekpour Tehrani 1 ORCID logo, Marziyeh Dehghani 1 ORCID logo, Alireza Jafari 1 ORCID logo

1 Department of Internal Medicine, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding author: Rahil Riahi Samani, Email: riahi.r@skums.ac.ir , rahilriahi200@gmail.com

Abstract

Introduction: There is a high risk of diabetes mellitus in pre-diabetic patients.

Objectives: The aim of the study was to compare the effect of the extracts of these herbs in the formulation of Glucoherb supplementation versus metformin in pre-diabetes patients on glycemic markers and glycosylated hemoglobin.

Patients and Methods: Pre-diabetic patients who had indication of drug treatment according to the criteria of the American Diabetes Association, were selected and randomly divided into two groups of Glucoherb and metformin. Body mass index (BMI), fasting blood sugar (FBS), 2 hours postprandial blood glucose (BS2PP) and glycosylated hemoglobin (HbA1c) were measured before and after the intervention.

Results: The mean BMI, FBS, BS2PP and HbA1c levels were significantly decreased after intervention in both Glucoherb and metformin groups (P < 0.05) without any significant difference between them (P < 0.05).

Conclusion: Glucoherb showed similar efficacy to metformin in reducing blood glucose, BMI and HbA1c in pre-diabetic patients.

Keywords: Glucoherb, Diabetes mellitus, Fasting blood sugar, Glycated hemoglobin, Metformin, Pre-diabetic

Implication for health policy/practice/research/medical education:

In a clinical trial, the effect of Glucoherb supplementation as a combination of some herbal drugs versus metformin on glycemic markers and glycosylated hemoglobin in pre-diabetes patients was compared. We found, the body mass index (BMI), fasting blood sugar (FBS), 2 hours postprandial blood glucose (BS2PP) and glycosylated hemoglobin (HbA1c) levels significantly decreased after intervention in both Glucoherb and metformin groups without any significant difference between them. We concluded that Glucoherb had similar efficacy to metformin in reducing blood glucose, BMI and Hb1AC in pre-diabetic patients.

Please cite this paper as: Izadi I, Riahi Samani R, Malekpour Tehrani A, Dehghani M, Jafari A. Glucoherb versus metformin on glycemic markers and glycosylated hemoglobin in prediabetes patients; a clinical trial study. J Nephropharmacol. 2021;10(1):08. DOI: 10.34172/npj.2021.08.

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