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Submitted: 16 Oct 2020
Accepted: 10 Nov 2020
ePublished: 26 Nov 2020
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J Nephropharmacol. 2021;10(2): e19.
doi: 10.34172/npj.2021.19
  Abstract View: 30
  PDF Download: 8

Mini Review

Understanding kidney injury in COVID-19; a pressing priority

Elham Ahmadipour 1, Bhaskar VKS Lakkakula 2 ORCID logo, Golnaz Vahdani 3 ORCID logo, Ramin Tolouian 4 ORCID logo, Hedieh Ragati Haghi 5 ORCID logo, Doris Delgado 6 ORCID logo, Luiz Augusto Fernandes da Silva 7, Masoud Hafizi 8 * ORCID logo

1 Nickan Research Institute, Isfahan, Iran
2 Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur, India
3 Division of Nephrology, University of Arizona, Tucson, AZ, USA
4 Renal Section, Southern Arizona VA Health Care System, Tucson, AZ, USA
5 Department of Radiology, Brigham and Women’s Hospital, Boston, MA, USA.
6 Independent Researcher and Consultant, 101 East Coso Street Suite 656 Ridgecrest, Ca, USA
7 Departament of Nephrology, Life Center Hospital Belo Horizonte, Minas Gerais, Brazil
8 Department of Infectious Diseases, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding author: Masoud Hafizi, Email: massoud_hafizi@yahoo.com

Abstract

The 2019 novel coronavirus disease (COVID-19) is a newly defined infectious and highly contagious acute disease caused by the severe acute respiratory syndrome coronavirus 2 ( (SARS-CoV-2). COVID-19 is mainly characterized by an acute respiratory disease however it can also affect multiple other organ systems such as the kidney, gastrointestinal tract, heart, vascular system, and the central nervous system. Kidney involvement is frequent in patients with COVID-19 and this review aims to explore the available data on kidney and COVID-19. In conclusion, COVID-19 infection can affect renal function and may cause acute kidney injury (AKI), due to several mechanisms that need to be fully elucidated. As only supportive management strategies are available for treating AKI in COVID-19, it is necessary to identify and preserve renal function during SARS-CoV-2 infection.
Keywords: COVID-19, Kidney injury, Renal transplant, Hemodialysis, Angiotensin-converting enzyme 2, Cytokine storm, SARS-CoV-2, Acute kidney injury

Implication for health policy/practice/research/medical education:

Numerous studies have shown that, acute kidney injury was independently associated with higher mortality in COVID-19.

Please cite this paper as: Ahmadipour E, Lakkakula BVKS, Vahdani G, Tolouian R, Ragati Haghi H, Delgado D, da Silva LAF, Hafizi M. Understanding kidney injury in COVID-19; a pressing priority. J Nephropharmacol. 2021;10(2):e19. DOI: 10.34172/ npj.2021.19.

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