Submitted: 30 Jan 2019
Accepted: 10 May 2019
ePublished: 03 Jun 2019
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J Nephropharmacol. 2020;9(1): e03.
doi: 10.15171/npj.2020.03

Scopus ID: 85084807369
  Abstract View: 1619
  PDF Download: 821


Hazardous effect of the maintenance dose of iron sucrose versus iron dextran on oxidative burst activity of neutrophils in patients on regular hemodialysis; a pilot study

Iman Ibrahim Sarhan 1, Maha Abdelmoneim Behairy 1 * , Hoda Mohamed El Sayed 2, Doaa Mohamed Abdelaziz 3

1 Internal Medicine and Nephrology Department, Ain Shams University, Cairo, Egypt
2 Internal Medicine and Immunology Department, Ain Shams University, Cairo, Egypt
3 Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
*Corresponding author: Maha Abdelmoneim Behairy, E mail: mahabehairy@med.asu.edu.eg & Mahabehairy80@gmail.com


Introduction: Intravenous (IV) iron which is a potent pro-oxidant may decrease the phagocytic function of neutrophils and subsequently leads to repeated bacterial infections in patients on chronic regular hemodialysis (HD).Objectives: We aimed to evaluate the effect of IV iron dextran versus iron sucrose on oxidative burst activity of neutrophils in HD patients.Patients and

Methods: A crossover study was included 20 prevalent HD patients were randomly divided into two groups; 10 patients each. Each group received a single dose of 100 mg iron sucrose or iron dextran then shifted to the other type after 4 weeks as a washout period. Patients with evidence of acute infections, diabetes mellitus, chronic liver disease, active collagen disease or any other acquired immune deficiency diseases were excluded. Patients on immunosuppressive drugs or with hypersensitivity to iron therapy or evidence of iron overload (TSAT > 50% and/or ferritin > 800 ng/mL) were also excluded. Erythropoietin maintenance dose was given to all patients. Urea reduction ratio (URR %), C-reactive protein (CRP) titer, complete blood picture and iron study were conducted. Neutrophil oxidative burst test was performed by flow-cytometry with an estimation of stimulation index before and after IV iron dosage.

Results: Twenty patients (9 males, 11 females; mean age 49.40 ± 9.02 years) on chronic HD for a mean time of 10 ± 7.32 years. After 100 mg of IV iron infusion in HD patients, a highly significant difference in oxidative burst test of neutrophil cells before and after administration of iron regardless of its type was detected (P < 0.01). This change over time is not significantly different between two types of iron (P > 0.05). However, a significant increase in CRP titer after administration of iron dextran was seen (P = 0.016).

Conclusion: Maintenance dosage of either IV iron sucrose or iron dextran (100 mg) had a hazardous effect on the neutrophilic phagocytosis demonstrated by the significant rise in the oxidative burst index in HD patients.

Keywords: Iron therapy, Neutrophils, Hemodialysis, Flow-cytometry, End-stage renal disease, Oxidative burst test, Reactive oxygen species, Chronic kidney disease

Implication for health policy/practice/research/medical education:

In a clinical study on a group of regular hemodialysis patients we found, both commercial types of IV iron (dextran or sucrose) significantly increased the neutrophil cells oxidative burst stimulation index after 48 hours. Chronic renal failure is becomingly increasing in incidence and there is a world-wide administration of iron preparations in these patients. Better understanding and cautious use of these preparations are needed to get the most benefit from it while reducing the risks.

Please cite this paper as: Sarhan II, Behairy MA, El Sayed HM, Abdelaziz DM. Hazardous effect of the maintenance dose of iron sucrose versus iron dextran on oxidative burst activity of neutrophils in patients on regular hemodialysis; a pilot study. J Nephropharmacol. 2019;8(2):x-x. DOI: 10.15171/npj.2019.xx

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