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Submitted: 05 Mar 2019
Accepted: 07 Jun 2019
First published online: 29 Jun 2019
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J Nephropharmacol. 2020;9(1): ee05.
doi: 10.15171/npj.2020.05
  Abstract View: 138
  PDF Download: 229

Original

Investigation of factors related to N-terminal pro-B type natriuretic peptide levels in hemodialysis patients; a single center study

Farbod Bonakdar 1, Pegah Noorshargh 2 ORCID logo, Parin Hedayati 3, Hamid Nasri 1 * ORCID logo

1 Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
3 Hemodialysis Section, Amin Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding author: Prof. Hamid Nasri, Email; Email: hamidnasri@med.mui.ac.ir

Abstract

Introduction: Introduction: N-terminal pro-B type natriuretic peptide (NT-proBNP) can be used to diagnose cardiac and renal disease. The association of NT-pro BNP with demographic, clinical and biochemical factors in hemodialysis is unclear.

Objectives: This study aimed to examine association of NT-pro BNP and mentioned factors in hemodialysis patients.

Patients and Methods: This study was conducted on 78 end-stage renal disease (ESRD) patients under hemodialysis. Demographic data, lipid profile and electrolytes were recorded. NT-proBNP was checked simultaneously and its association with mentioned factors were assessed.

Results: The average NT-pro BNP level was 890.52±700.87 pg/mL (range: 0.1-3343 pg/mL). Serum level of NT-pro BNP was statistically in association with total cholesterol (P=0.002; r=-0.348), low density lipoprotein (LDL) (P=0.09; r= -0.292), high density lipoprotein (HDL) (P=0.06; r=-0.310) and serum triglyceride (P=0.018; r=-0.269) while having a direct relationship with serum ferritin (P=0.022; r=0.274), alkaline phosphatase (ALP) (P=0.048; r=0.224) and duration of hemodialysis (P=0.005; r=0.321).

Conclusion: Lipid profile and ferritin are associated with NT-pro BNP levels. This can reflect possible prognostic role of NT-proBNP among ESRD patients on hemodialysis.

Keywords: N-terminal pro-B type natriuretic peptide, Renal insufficiency, Renal dialysis, End-stage renal disease, Hemodialysis, Chronic kidney disease

Implication for health policy/practice/research/medical education:

In a study on 78 end-stage renal disease patients under hemodialysis, we found serum level of NT-pro BNP was statistically in association with total cholesterol, LDL, HDL and serum triglyceride while having a direct relationship with ferritin, ALP and duration of hemodialysis.

Please cite this paper as: Bonakdar F, Noorshargh P, Hedayati P, Nasri H. Investigation of factors related to N-terminal pro-B type natriuretic peptide levels in hemodialysis patients; a single center study. J Nephropharmacol. 2019;8(2):x-x. DOI: 10.15171/ npj.2019.xx.

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