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Submitted: 05 Feb 2019
Accepted: 12 May 2019
First published online: 20 Jul 2019
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J Nephropharmacol. 2020;9(1): ee02.
doi: 10.15171/npj.2020.02
  Abstract View: 67
  PDF Download: 89

Original

Renal damages in patients with major β-thalassemia

Malihe Najafpour 1 ORCID logo, Majid Farshdousti-Hagh 2 * ORCID logo, Ali Akbar Movasagpoor-Akbari 2 ORCID logo, Abbas-Ali Hosein-Pour Feyzi 2, Majid Malaki 2 ORCID logo

1 Medical Biotechnology Research Center, School of Nursing, Midwifery and Paramedical, Guilan University of Medical Sciences, Rasht, Iran
2 Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding author: Majid Farshdousti Hagh, Email: Email: m.farshdousti@gmail.com

Abstract

Introduction: Numerous studies have shown the presence of renal dysfunction in patients with beta thalassemia major (βTM). According to iron overload and effects on renal, evaluation of renal function in βTM can cause better control of them.

Objectives: In this study, we evaluated renal function in children and adults with βTM. Patients and

Methods: Sixty patients (38 male and 22 female) with βTM, and 60 healthy control subjects (25 males and 35 females), were participated in this cross-sectional study. Biochemical and urine analysis were conducted to evaluate renal function. Additionally, patients were classified based on the administration of iron chelators including deferoxamine (Desferal), deferiprone (L1), deferasirox (Exjade) and combination therapy.

Results: Renal dysfunctions such as hyperfiltration and proteinuria were common findings in patients compared with the normal group. Hypercalciuria was found only in patients groups receiving Exjade. Hyperfiltration was detected in all patients. Proteinuria was no related to drug administration.

Conclusion: We found a high percentage of our βTM patients who had renal dysfunction as evidenced by proteinuria and hyperfiltration.

Keywords: Thalassemia, Renal function, Iron chelator therapy

Implication for health policy/practice/research/medical education:

Renal dysfunction is a side effect of blood transfusion in patients suffering from beta thalassemia major (βTM). It seems that high percentage of patients with βTM have renal dysfunction as evidenced by proteinuria and hyperfiltration. Hypercalciuria and hyperfiltration are some of the side effects of iron chelator agents.

Please cite this paper as: Najafpour M, Farshdousti-Hagh M, Movasagpoor-Akbari AK, Hosein-Poor Feyzi AA, Malaki M. Renal damages in patients with major β-thalassemia. J Nephropharmacol. 2020;9(1):e02. DOI: 10.15171/npj.2020.02

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