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Submitted: 18 Jun 2019
Accepted: 03 Sep 2019
ePublished: 19 Oct 2019
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J Nephropharmacol. 2020;9(2): e16.
doi: 10.34172/npj.2020.16

Scopus ID: 85085890675
  Abstract View: 205
  PDF Download: 94

Original

The K469E genetic variant in the ICAM1 gene is associated with type 2 diabetes but not with its vascular complications: a meta-analysis

Saikrishna Lakkakula 1 ORCID logo, Henu Kumar Verma 2 ORCID logo, Bhaskar V.K.S. Lakkakula 3 * ORCID logo

1 Department of Zoology, Visvodaya Government Degree College, Venkatagiri, India
2 Stem Cell Laboratory, Institute of Endocrinology and Oncology, Naples, Italy
3 Sickle Cell Institute Chhattisgarh, Raipur, India
*Corresponding author: Bhaskar V. K. S. Lakkakula, Email: lvksbhaskar@gmail.com

Abstract

Introduction: Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by diminished insulin secretion and hyperglycemia leading to damage of multiple organs. The present study is aimed to test the association between type 2 diabetes vascular complications and K469E variant (rs5498) of the intercellular adhesion molecule-1 (ICAM1) gene.

Methods: Online databases were searched to retrieve all publications relating to the ICAM1 rs5498 variant in human diabetic vascular complications. In the present meta-analysis, we included all eligible studies and calculated the pooled results using MetaGenyo web tool.

Results: Studies concerning ICAM1 gene K469E variant association with either type 2 diabetes or diabetes related vascular complications were included in this meta-analysis. Fifteen articles were included in this analysis (n=10 for T2DM; n=5 for diabetes nephropathy; n=8 for diabetes retinopathy). ICAM1 K469E variant significantly increased the risk of T2DM in the allelic (OR = 1.10, 95% CI: 1.01-1.20, P = 0.032) and recessive models (OR = 1.27, 95% CI: 1.08-1.49, P = 0.004). However, the ICAM1 gene K469E variant is not associated with diabetic nephropathy or diabetic retinopathy. No noticeable evidence of publication bias was detected.

Conclusion: In summary, our study indicated that ICAM1 K469E variant was significantly associated with the increased risk of diabetes but not with the diabetic vascular complications.

Keywords: Type 2 diabetes, Retinopathy, Nephropathy

Implication for health policy/practice/research/medical education:

Diabetes mellitus is a chronic metabolic disease characterised by diminished insulin secretion and hyperglycemia leading to damage of multiple organs. Intracellular adhesion molecule 1 (ICAM1) is a cell surface glycoprotein that expressed in endothelial cells as well as leucocytes. Several studies have examined the relationship between ICAM1 K469E genetic variant and diabetic vascular complications; however, the results are inconclusive. We performed a meta-analysis of ICAM1 K469E studies. Our study indicated that the ICAM1 K469E variant was significantly associated with the increased risk of diabetes, but not with the diabetic vascular complications.

Please cite this paper as: Lakkakula S, Verma HK, Lakkakula BVKS. The K469E genetic variant in the ICAM1 gene is associated with type 2 diabetes but not with its vascular complications: a meta-analysis. J Nephropharmacol. 2020;9(2):e16. DOI: 10.34172/ npj.2020.16.

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