Society of Diabetic Nephropathy Prevention Journal of Nephropharmacology 2345-4202 11 2 2022 07 09 Acquired hemophilia in a patient with SARS-CoV-2 infection; a case report e10453 e10453 10.34172/npj.2022.10453 EN Ali Hajigholami https://orcid.org/0000-0001-6467-2971 Hourieh Ansari https://orcid.org/0000-0002-2468-5345 Sakineh Ansari https://orcid.org/0000-0001-7069-2178 Shakiba Hassanzadeh https://orcid.org/0000-0002-5091-5191 Journal Article 10.34172/npj.2022.10453 2021 11 04 2021 12 07 Acquired hemophilia (AH) is a potentially life-threatening hemorrhagic disorder. We report the second confirmed case of COVID-19-associated AH in a 45-year-old female which, unfortunately, expired as her treatment failed. She presented to the emergency department with abnormal bleeding and spontaneous hemoptysis about ten days after a removal surgery of her epiglottis tumor. Aggregation tests, such as partial thromboplastin time (PTT), are recommended in patients with COVID-19 infection that have bleeding episodes.