Society of Diabetic Nephropathy Prevention Journal of Nephropharmacology 2345-4202 13 2 2024 06 29 Association between triglyceride-glucose index and risk of chronic kidney disease: a systematic review and meta-analysis e12692 e12692 10.34172/npj.2024.12692 EN Muhanad Muhussin Ali https://orcid.org/0009-0006-6071-4672 Raed Muslim Mhaibes https://orcid.org/0000-0002-4835-0873 Mohammed Abdul-Mounther Othman https://orcid.org/0000-0002-9728-2467 Qais R. Lahhob https://orcid.org/0000-0001-5259-8946 Mohammed Jasim Qasim Journal Article 10.34172/npj.2024.12692 2024 03 25 2024 06 23 Introduction: The triglyceride-glucose index (TyG) is a reliable alternative marker for insulin resistance. Since insulin resistance is a risk factor for chronic kidney disease (CKD). Objectives: This study aimed to investigate the relationship between the TyG index and CKD using the systematic review method and meta-analysis. Material and Methods: The required sources were searched using the databases Cochrane, Web of Science, PubMed, ProQuest, and Google Scholar Search Engine without a time limit. STATA 14 software was conducted for data analysis, and tests with p-values lower than 0.05 (P < 0.05) were considered statistically significant. Results: Findings from 20 research with a total of 277986 samples demonstrated that high TyG index increased the risk of CKD in the total population, female patients, and male patients by 37% (OR: 1.37, 95% CI: 1.25, 1.5), 38% (OR: 1.38, 95% CI: 1.19, 1.61), and 31% (OR: 1.31, 95% CI: 1.13, 1.50), respectively. Furthermore, high TyG levels in individuals younger than 55 and those aged 55 or higher increased the risk of CKD by 54% (OR: 1.54, 95% CI: 1.36, 1.74) and 23% (OR: 1.23, 95% CI: 1.14, 1.32), respectively. Nevertheless, Australia (OR: 1.68, 95% CI: 1.56, 1.81) indicated the strongest and Singapore (OR: 1.21, 95% CI: 1.06, 1.38) showed the weakest relationship between the TyG index and the risk of CKD. However, higher TyG indices increased the risk of CKD in cohort and cross-sectional studies by 35% (OR: 1.35, 95% CI: 1.20, 1.51) and 41% (OR: 1.41, 95% CI: 1.29, 1.55), respectively. Conclusion: A high TyG index increases the risk of CKD, and women and individuals younger than 55 are the high-risk groups. Registration: This study has been compiled based on the PRISMA checklist, and its protocol was registered on the PROSPERO (ID: CRD42024544037) and Research Registry (UIN: reviewregistry1829) website.