Society of Diabetic Nephropathy Prevention Journal of Nephropharmacology 2345-4202 7 2 2018 05 20 Diagnosis and predictive clinical and para-clinical cutoffs for diabetes complications in Lur and Lak populations of Iran; a ROC curve analysis to design a regional guideline 83 89 10.15171/npj.2018.19 EN Babak Khodadadi Nazanin Mousavi Mahshad Mousavi Parastoo Baharvand Seyyed Amir Yasin Ahmadi Journal Article 10.15171/npj.2018.19 2018 02 11 2018 07 25 Introduction: American Diabetes Association updates its guideline every year. However this guideline can be changed for different populations based on their cultural and genetic status. Objectives: We intend to design a regional study in Lur and Lak populations of Iran using receiver operating characteristics (ROC) curve model. Results: For neuropathy, age was the most accurate diagnostic index (area under curve [AUC] = 79%). For nephropathy SBP was the most accurate diagnostic index (AUC= 88%). For symptomatic retinopathy DM duration was the most accurate diagnostic index (AUC= 81%). For PVD, HDL-C was the most accurate diagnostic index (reverse AUC= 67%). For CVD age was the most accurate diagnostic index (AUC= 81%). For foot ulcer history age was the most accurate diagnostic index (AUC= 85%). Conclusion: The final suggested guideline is like the international guidelines. However some unique points should be regarded. Blood pressure >165/110 mm Hg is diagnostic of diabetic nephropathy. Additionally serum high-density lipoprotein (HDL-C) >48 mg/dL is strongly suggested.