Saeed Mardani
1, Hamid Nasri
2, Mahmoud Rafieian-Kopaei
3*, Seyed Seifollah Beladi Mousavi
41 Department of Nephrology, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran
3 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
4 Department of Internal Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
*Corresponding Author: *Corresponding author: Prof. Mahmoud Rafieian-Kopaei, Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran., Email:
rafieian@yahoo.com
Implication for health policy/practice/research/medical education
Studies have shown that elevated uric acid levels have a deleterious effect, directing to endothelial dysfunction, inflammation, and vascular disease. Elevated uric acid initiates endothelial dysfunction by inhibiting nitric oxide synthetase, activating the renin-angiotensin system and causing pro-inflammation with leads to endothelial dysfunction, vascular smooth muscle cell dysfunction, and finally contributing to atherosclerosis and vascular dysfunction and aggravation of diabetic kidney disease and IgA nephropathy and other nephropathies. While various clinical investigations have shown that, lowering uric acid with allopurinol improved endothelial dysfunction in both hyperuricemic subjects and hypertensive type 2 diabetic patients with normal uric acid levels. We therefore suggest, further clinical studies, to better find the allopurinol kidney protective properties in diabetes, IgA nephropathy or other nephropathies.
Please cite this paper as: Mardani S, Nasri H, Rafieian-Kopaei M, Beladi Mousavi SS. Hyperuricemia; a new look at an old problem. J Nephropharmacol 2012; 1(2): 13-14.