Alaleh Gheissari
*1 Department of Pediatric Nephrology, Isfahan University of Medical Sciences, Isfahan, Iran
Implication for health policy/practice/research/medical education:
Focal segmental glomerulosclerosis (FSGS) is one of the principal causes of end-stage kidney disease in children worldwide. During the past decades, different genes mutations have been implicated in pathogenesis of resistant sporadic and hereditary familial forms of FSGS. Nephrin, podocin, alpha-actinin 4 (ACTN4) are some of podocyte structural proteins that their role in pathogenesis of FSGS have already been discussed. However, the role of TRPC6, a transient receptor potential ion channel, in hereditary forms of FSGS has been discovered. Regarding the roles of TRPC6 channels in proteinuria new trends to use TRPC6 blocking agents though challenging are developed.
Please cite this paper as: Gheissari A. Focal segmental glomerulosclerosis and end-stage kidney disease in children. J Nephropharmacol. 2015;4(2):61-62.