Implication for health policy/practice/research/medical education:
Endothelial nitric oxide plays a crucial role in the control of local hemodynamics and systemic blood pressure. Thus, it has been proposed that gene coding for endothelial nitric oxide synthase (eNOS) could have a modifying effect on hypertension and related complications in autosomal dominant polycystic kidney disease (ADPKD). As endothelial dysfunction and oxidative stress are evident early in ADPKD patients, eNOS holds therapeutic promise in the treatment of ADPKD.
Please cite this paper as: Wiwanitkit V. Nitric oxide synthase and polycystic kidney disease. J Nephropharmacol. 2015;4(2):85-87.