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Submitted: 07 Jun 2020
Accepted: 18 Sep 2020
ePublished: 17 Oct 2020
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J Nephropharmacol. 2021;10(2): e16.
doi: 10.34172/npj.2021.16
  Abstract View: 265
  PDF Download: 104

Review

Potential of renin-angiotensin system inhibition to improve metabolic bone disorders

Mahnaz Momenzadeh 1 * ORCID logo, Maryam Khosravian 2 ORCID logo, Bhaskar VKS Lakkakula 3 ORCID logo

1 Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
2 Institute of Biology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
3 Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur, India
*Corresponding author: Mahnaz Momenzadeh, Email: mahnazmomenzadehf@gmail.com

Abstract

Metabolic bone disorder is an abnormality of bones indicated by reduced bone mass and high risk of fractures. Several lines of evidence have demonstrated that the local bone tissue renin-angiotensin system (RAS) is directly involved in bone metabolism and influences the bone health. This review aimed to assess the role of RAS in bone metabolism and comparative effectiveness of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in reducing the bone fractures. In summary, the clinical trials, in vivo studies, and functional - pharmacological experiments suggested that the RAS regulates bone marrow metabolism and influences the bone health. Hence, it warrants further investigation on the role of ACEIs and ARBs in reducing risk fractures.
Keywords: Metabolic bone disorder, Renin-angiotensin system, Dual blockade

Implication for health policy/practice/research/medical education:

Several studies have demonstrated that the local bone tissue renin-angiotensin system (RAS) is directly involved in bone metabolism and influences the bone health.

Please cite this paper as: Momenzadeh M, Khosravian M, Lakkakula BVKS. Potential of renin-angiotensin system inhibition to improve metabolic bone disorders. J Nephropharmacol. 2021;10(2):e16. DOI: 10.34172/npj.2021.16.

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