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Submitted: 11 Nov 2020
Accepted: 29 Dec 2020
ePublished: 13 Jan 2021
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J Nephropharmacol. 2024;13(1): e10381.
doi: 10.34172/npj.2022.10381
  Abstract View: 7912
  PDF Download: 376

Original

Comparative study of nephroprotective effects of resveratrol and silymarin in diabetic rats; an experimental histopathologic study

Elnaz Golestaneh 1 ORCID logo, Ali Hasanpour Dehkordi 2 ORCID logo, Banafsheh Yalameha 3 ORCID logo, Pegah Noorshargh 4 ORCID logo, Parto Nasri 5 ORCID logo, Hamid Nasri 6* ORCID logo

1 Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
2 Social Determinants of Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
4 Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
5 Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
6 Department of Internal Medicine, Isfahan, University of Medical Sciences, Isfahan, Iran
*Corresponding Author: Prof. Hamid Nasri, Email: hamidnasri@med.mui.ac.ir

Abstract

Introduction: Diabetes mellitus (DM) is distinguished as a serious health problem worldwide. The universal outbreak of DM because of urban life and alteration of lifestyle, day to day is increasing.

Objectives: The present investigation was designed to evaluate the nephroprotective effects of resveratrol (RSV) and silymarin (SM) on morphologic injury to renal tubular cells in adult male diabetic rats.

Materials and Methods: Twenty-five male Wistar rats randomly were designated into five groups (n = 5) including group I (control); rats received normal saline by gavage for 14 days. Group II; rats received a single injection of STZ at a dose of 60 mg/kg intraperitoneally and were also given isotonic saline orally for 14 days. Group III; Rats, after STZ injection, received 100 mg/kg of SM by gavage for 14 days. Group IV; Rats, after STZ injection, received 100 ml/kg of RSV by gavage for 14 days. Group V; rats, after STZ injection, received the combination of SM and RSV at a dose of 100 mg/kg by gavage for 14 days. The kidneys were removed immediately after sacrificing and prepared for morphological examination. Kidney sections were examined for the intensity of kidney damage (vacuolization, flattening, degeneration and necrosis).

Results: Significant differences were observed in types of morphologic injury to renal tubular cells (vacuolization, flattening, degeneration and necrosis) between groups (P<0.05). Significantly, both the SM and RSV reduced the injury of renal tubular cells in diabetic rats (P<0.05).

Conclusion: The findings of the present study indicated that although the protective effect of SM and RSV was more significant on necrosis and flattening, respectively, SM and RSV produced a nephroprotective impact on the injury of renal tubular cells in diabetic rats than their combination influences.


Implication for health policy/practice/research/medical education:

Our experimental study on 25 male Wistar rats indicated that resveratrol and silymarin can produce a nephroprotective impact on the injury of renal tubular cells in diabetic rats than their combination influences. Additionally, the protective effect of resveratrol and silymarin was more significant on necrosis and flattening, respectively.

Please cite this paper as: Golestaneh E, Hasanpour Dehkordi A, Yalameha B, Noorshargh P, Nasri P, Nasri H. Comparative study of nephroprotective effects of resveratrol and silymarin in diabetic rats; an experimental histopathologic study. J Nephropharmacol. 2024;13(1):e10381. DOI: 10.34172/npj.2022.10381.

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