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Submitted: 14 Dec 2020
Accepted: 17 Feb 2021
ePublished: 29 May 2021
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J Nephropharmacol. 2021;10(2): e21.
doi: 10.34172/npj.2021.21
  Abstract View: 241
  PDF Download: 118

Original

A study on the correlation of serum magnesium with intima-media thickness of carotid in hemodialysis patients

Taraneh Esmaili 1 ORCID logo, Zahra Aghaalitafreshi 2 ORCID logo, Mohammad Hadi Gharib 3 ORCID logo, Maryam Montazeri 4 * ORCID logo

1 Assistant Professor of Nephrology, Sayyad Shirazi Hospital Research Center, Dialysis Center of the 5th Azar Hospital, Golestan University of Medical Sciences, Gorgan, Iran
2 MD, Internal Medicine, Golestan University of Medical Sciences, Gorgan, Iran
3 Assistant Professor of Radiology, Golestan University of Medical Sciences, Gorgan, Iran
4 Medical Doctor, Infectious Research Center of Sayyed Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran
*Corresponding author: Maryam Montazeri, Email: Marine.montazeri@yahoo.com

Abstract

Introduction: Atherosclerosis progression in the patients suffering from end-stage renal disease (ESRD) is more than normal population. Magnesium levels are also associated with an increase in atherosclerosis in the common carotid artery. Intima-media carotid calcification is either directly or indirectly related to cardiovascular disease and a higher rate of death among patients with chronic renal failure.

Objectives: The purpose of the present study was to evaluate the protective role of serum magnesium levels in vascular calcification and the improvement of the carotid intima-media thickness (CIMT).

Patients and Methods: In this cross-sectional research, the participants were selected from all patients with ESRD in Five Azar Medical Center of Gorgan, Iran. Blood samples collected from research units were tested for serum magnesium level in three times. Patients were referred to a radiologist to measure CIMT. Data collected in all patients were evaluated based on Spearman’s correlation test.

Results: The correlation between serum magnesium level and CIMT was not statistically significant (P = 0.66 r= 0.04), however a positive correlation between CIMT and the dialysis adequacy (KT/V) was detected (r = 0.306, P = 0.006).

Conclusion: This study demonstrated no correlation between the serum magnesium level and the CIMT in hemodialysis patients.

Keywords: Magnesium, Hemodialysis, Intima-media, Carotid artery

Implication for health policy/practice/research/medical education:

Changes in serum magnesium (Mg) may affect some clinical features of patients on maintenance hemodialysis (HD). In HD patients, lower magnesium levels were reported to be associated with increased atherosclerosis of the common carotid artery. So we conducted this study to assess the hypothesis that serum magnesium level of the HD patients can be related to carotid intima media thickness; as the consequences have not been clearly recognized in the Iranian people. It would be useful to provide some clinical recommendations for the prediction of CVD and implement prevention programs for high-risk hemodialysis patients.

Please cite this paper as: Esmaili T, Aghaalitafreshi Z, Gharib MH, Montazeri M. A study on the correlation of serum magnesium with intima-media thickness of carotid in hemodialysis patients. J Nephropharmacol. 2021;10(2):e21. DOI: 10.34172/npj.2021.21.

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