Submitted: 14 Jun 2021
Accepted: 07 Aug 2021
ePublished: 30 Aug 2021
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J Nephropharmacol. 2022;11(1): e1.
doi: 10.34172/npj.2022.01

Scopus ID: 85119343454
  Abstract View: 508
  PDF Download: 204


Kidney complications following COVID-19 vaccination; a review of the literature

Shakiba Hassanzadeh 1 ORCID logo, Arjang Djamali 2 ORCID logo, Leila Mostafavi 3 ORCID logo, Aiyoub Pezeshgi 4* ORCID logo

1 Division of Pathology, Nickan Research Institute, Isfahan, Iran
2 Division of Nephrology, Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA
3 Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
4 Department of Internal Medicine and Zanjan Metabolic Disease Research Center, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
*Corresponding Author: *Corresponding author: Aiyoub Pezeshgi, Email: , Email: Dr.a.pezeshki@gmail.com


Objective: To review the reported cases of kidney injury following vaccination for coronavirus disease 2019 (COVID-19) with a focus on renal pathology.

Methods: We searched for case reports of kidney complications after COVID-19 vaccine in PubMed.

Results: A total of 36 articles including 49 case reports were reported. These included minimal change disease (n=17), IgA nephropathy (IgAN) (n=15), IgA nephritis/vasculitis (n=5), ANCA glomerulonephritis/vasculitis (n=5), anti-glomerular basement membrane (GBM) nephritis (n=2), and 1 case of each granulomatous vasculitis, acute tubulointerstitial nephritis, scleroderma renal crisis, IgG4-related disease nephritis, and primary membranous nephropathy (MN).

Conclusion: We give an overview of the reported cases of post-COVID-19 renal complications. Further investigations of the underlying pathogenesis of post-COVID-19 vaccination renal adverse events are required, as prompt workup, diagnosis, and treatment of patients with renal complications may lead to complete remission, prevent kidney failure, and long-term complications such as end-stage renal disease (ESRD). However, these complications are overall extremely rare and the benefit of vaccination outweighs the potential risks.

Implication for health policy/practice/research/medical education:

Immediate consideration, diagnosis, and treatment of renal complications in the post-COVID-19 vaccination period may prevent long-term renal complications such as end-stage renal disease. In addition, the pharmacovigilance of COVID-19 vaccines may help determine the incidence of side effects.

Please cite this paper as: Hassanzadeh S, Djamali A, Mostafavi L, Pezeshgi A. Kidney complications following COVID-19 vaccination; a review of the literature. J Nephropharmacol. 2022;11(1):e01. DOI: 10.34172/npj.2022.01.

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