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Submitted: 13 Jun 2022
Accepted: 20 Aug 2022
ePublished: 27 Aug 2022
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J Nephropharmacol. 2023;12(1): e10526.
doi: 10.34172/npj.2022.10526
  Abstract View: 8413
  PDF Download: 1575

Clinical Trial

Durability of the two-lumen catheter in hemodialysis patients; Ethanol 70%-heparin versus cefazolin-heparin: a randomized, double-blind clinical trial study

Hadi Yousefi 1 ORCID logo, Mehdi Hosseinifard 2 ORCID logo, Mojgan Falaki 3 ORCID logo, Fariba Asadi Noghabi 2 ORCID logo, Hamidreza Samimagham 4 ORCID logo, Mohsen Yousefi 5 ORCID logo, Hossein Mardanparvar 6 ORCID logo, Jahanbakhsh Vahdatnejad 7* ORCID logo

1 Department of Community Medicine, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
2 Mother and Child Welfare Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
3 Department of Internal Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
5 Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6 Department of Nursing, Faculty of Nursing and Midwifery, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
7 Clinical Research Development Unit, Imamsajad Hospital, Yasuj University of Medical Sciences, Yasuj, Iran
*Corresponding Author: Corresponding author: Jahanbakhsh Vahdatnejad, Email: Jahan.vahdat@gmail.com, , Email: vahdatnejad.jahan@yums.ac.ir

Abstract

Introduction: Maintenance of hemodialysis catheters is essential for the patients and medical staff due to their repeated use for hemodialysis and other therapeutic interventions in the hospital.

Objectives: This study aimed to comprise the effect of ethanol 70%-heparin versus cefazolin-heparin on the catheter durability time of hemodialysis patients.

Patients and Methods: The study population consisted of 73 hemodialysis patients referred to Shahid Mohammadi hospital in Bandar Abbas. Patients were divided into two groups cefazolin (cefazolin 5 mg/dL, and heparin 2500 IU/mL) and ethanol (ethanol 70%, and heparin 2500 IU/mL). In both groups, after each hemodialysis session, 2.9 to 3.3 mL of the locking solution was locked in the catheter lumen and remained until the next session. This intervention was conducted for all patients continuously for five months. The time of catheter durability was calculated from the time of catheter placement in the central vein until the time that it has been taken out according to the doctor’s diagnosis. Data were collected and analyzed by SPSS version 26.

Results: Results showed that demographic characteristics, including age, weight, gender, marital status, catheter type, underlying diseases, and dialysis adequacy between the two groups were similar (P>0.05). In the ethanol group, the mean time of the catheter durability was 27.5 days, and in the cefazolin group was 26.98 days. Although the time of the catheter durability was slightly higher in the ethanol group, this difference was not significant (P=0.194).

Conclusion: Cefazolin and ethanol 70% did not show a significant difference in the catheter durability time of hemodialysis patients.

Trial Registration: The trial protocol was approved by the Iranian Registry of Clinical Trials (IRCT20210811052145N1; https://en.irct.ir/trial/58037, ethical code; IR.HUNS.REC.1398.052).


Implication for health policy/practice/research/medical education:

In a clinical trial study on 73 hemodialysis patients, we found no significant difference in the effect of cefazolin versus ethanol 70% on catheter durability in hemodialysis patients.

Please cite this paper as: Yousefi H, Hosseinifard M, Falaki M, Asadi Noghabi F, Samimagham H, Yousefi M, Mardanparvar H, Vahdatnejad J. Durability of the two-lumen catheter in hemodialysis patients; Ethanol 70%-heparin versus cefazolin-heparin: a randomized, double-blind clinical trial study. J Nephropharmacol. 2023;12(1):e10526. DOI: 10.34172/npj.2021.10526.

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