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Submitted: 03 Jul 2023
Accepted: 10 Oct 2023
ePublished: 27 Oct 2023
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J Nephropharmacol. 2024;13(1): e10633.
doi: 10.34172/npj.2023.10633
  Abstract View: 754
  PDF Download: 221

Original

Investigation of the effects of oral dapoxetine on kidney function and histopathologic changes in male rats; an animal study and future perspectives

Alireza Akhavan Rezayat 1 ORCID logo, Amirabbas Asadpour 2 ORCID logo, Samaneh Boroumand-Noughabi 3 ORCID logo, Mona Kabiri 4,5 ORCID logo, Elham Ghafarian Baghaei Moghadam 6 ORCID logo, Alireza Nough Javazm 2* ORCID logo

1 Department of Urology, School of Medicine, Kidney Transplantation Complications Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of Urology, School of Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
3 Department of Hematology and Blood Bank, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4 Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Science, Mashhad, Iran
5 Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Science, Mashhad, Iran
6 Department of Gynecology and Obstructive, School of Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
*Corresponding Author: Alireza Nough Javazm, Email: me.end100@gmail.com, , Email: NoughjA981@mums.ac.ir

Abstract

Introduction: Dapoxetine is a novel therapeutic agent employed in treating specific diseases. However, its potential impact on renal excretion processes has yet to be thoroughly investigated, necessitating further exploration in this study.

Objectives: This research aimed to assess the effects of dapoxetine on renal function and explore any potential disturbances in kidney excretion processes.

Materials and Methods: In this study, 32 male Albino rats weighing between 200-250 g were utilized. The rats were randomly divided into four groups. Group one served as the control and received a normal diet, while groups two to four were administered dapoxetine through gavage at doses of 1 mg/kg, 2 mg/kg, and 4 mg/kg, respectively. The study evaluated blood urea nitrogen (BUN), and serum creatinine levels and examined renal pathological changes in the rats.

Results: The results demonstrated a significant increase in average BUN levels in group four compared to other groups (P<0.001). For creatinine, group three displayed higher levels compared to other groups. However, the difference was not statistically significant (P>0.05). Importantly, no indications of apoptosis, necrosis, edema, hydropic degeneration, or glomerular changes were observed in any of the renal cells from the rat groups.

Conclusion: Dapoxetine administration led to changes in BUN and creatinine levels; however, it did not adversely affect the renal cells’ pathological outcomes. These results suggest that dapoxetine could be considered for use in the future treatment of certain diseases, considering its minimal impact on renal function. Further investigations and clinical trials are warranted to corroborate these findings and inform medical decision-making.


Implication for health policy/practice/research/medical education:

Dapoxetine demonstrated no adverse effects on renal cells, indicating its potential safety for use in the treatment of certain diseases. However, it is important to consider the dose-dependent increase in blood urea nitrogen (BUN) with increasing dapoxetine dosage. Nevertheless, the absence of pathological changes in renal cells suggests that dapoxetine may offer a viable option for future treatments with minimal kidney-related side effects.

Please cite this paper as: Akhavan Rezayat A, Amirabbas Asadpour A, Boroumand-Noughabi S, Kabiri M, Ghafarian Baghaei Moghadam E, Nough Javazm A. Investigation of the effects of oral dapoxetine on kidney function and histopathologic changes in male rats; an animal study and future perspectives. J Nephropharmacol. 2024;13(1):e10633. DOI: 10.34172/npj.2023.10633.

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