Samaneh Zandifar
1 
, Leila Alem
1 , Azadeh Khayyat
2* , Mohammad Ali Esmaeil Pour
3 1 Nickan Research Institute, Isfahan, Iran
2 Department of Pathology, Resident Physician, Medical College of Wisconsin, Milwaukee, WI, USA
3 Department of Internal Medicine, Resident Physician, University of NC Health Blue Ridge, Morganton, NC, USA
Abstract
Membranous nephropathy is an immune complex disease caused by subepithelial deposits. The pathological manifestations of membranous nephropathy are considered by the creation of immune complexes in the epithelial cells of the glomerular basement membrane. The established pathologic features of primary membranous nephropathy include subepithelial immune deposits, thickening of the glomerular basement membrane, and podocyte foot process effacement. The clinical implications of pathological features of primary membranous nephropathy include male gender, age, persistent heavy proteinuria, decreased glomerular filtration rate on presentation, and tubulointerstitial fibrosis. Membranous nephropathy is diagnosed through a kidney biopsy, confirming subepithelial immune deposits, thickening of the glomerular basement membrane, and podocyte foot process effacement.
Implication for health policy/practice/research/medical education:
The Mayo Clinic consensus statement on membranous nephropathy suggests a new classification system for this condition. The new classification system is based on the presence or absence of certain features, such as immune deposits, glomerular basement membrane thickness, and the presence of certain genetic mutations. This new classification system aims to improve the diagnosis and therapy of this disease.
Please cite this paper as: Zandifar S, Alem L, Khayyat A, Esmaeil pour MA. The Mayo Clinic consensus report on membranous nephropathy; a promising step toward better treating the disease. J Nephropharmacol. 2024;13(2):e11657. DOI: 10.34172/npj.2023.11657.