Submitted: 25 Mar 2024
Accepted: 23 Jun 2024
ePublished: 29 Jun 2024
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J Nephropharmacol. 2024;13(2): e12692.
doi: 10.34172/npj.2024.12692
  Abstract View: 133
  PDF Download: 68

Meta Analysis

Association between triglyceride-glucose index and risk of chronic kidney disease: a systematic review and meta-analysis

Muhanad Muhussin Ali 1 ORCID logo, Raed Muslim Mhaibes 2* ORCID logo, Mohammed Abdul-Mounther Othman 2 ORCID logo, Qais R. Lahhob 3 ORCID logo, Mohammed Jasim Qasim 4

1 Department of Oral and Maxillofacial Surgery, College of Dentistry, Ashur University, Baghdad, Iraq
2 Department of Biochemistry College of Medicine, Missan University, Missan, Iraq
3 Collage of Pharmacy, National University of Science and Technology, Dhi Qar, 64001, Iraq
4 Department of Dentistry, Al-Manara college for Medical Sciences, Missan, Iraq
*Corresponding Author: Raed Muslim Mhaibes, Email: raid.mcm@uomisan.edu.iq


Introduction: The triglyceride-glucose index (TyG) is a reliable alternative marker for insulin resistance. Since insulin resistance is a risk factor for chronic kidney disease (CKD).

Objectives: This study aimed to investigate the relationship between the TyG index and CKD using the systematic review method and meta-analysis.

Material and Methods: The required sources were searched using the databases Cochrane, Web of Science, PubMed, ProQuest, and Google Scholar Search Engine without a time limit. STATA 14 software was conducted for data analysis, and tests with p-values lower than 0.05 (P < 0.05) were considered statistically significant.

Results: Findings from 20 research with a total of 277986 samples demonstrated that high TyG index increased the risk of CKD in the total population, female patients, and male patients by 37% (OR: 1.37, 95% CI: 1.25, 1.5), 38% (OR: 1.38, 95% CI: 1.19, 1.61), and 31% (OR: 1.31, 95% CI: 1.13, 1.50), respectively. Furthermore, high TyG levels in individuals younger than 55 and those aged 55 or higher increased the risk of CKD by 54% (OR: 1.54, 95% CI: 1.36, 1.74) and 23% (OR: 1.23, 95% CI: 1.14, 1.32), respectively. Nevertheless, Australia (OR: 1.68, 95% CI: 1.56, 1.81) indicated the strongest and Singapore (OR: 1.21, 95% CI: 1.06, 1.38) showed the weakest relationship between the TyG index and the risk of CKD. However, higher TyG indices increased the risk of CKD in cohort and cross-sectional studies by 35% (OR: 1.35, 95% CI: 1.20, 1.51) and 41% (OR: 1.41, 95% CI: 1.29, 1.55), respectively.

Conclusion: A high TyG index increases the risk of CKD, and women and individuals younger than 55 are the high-risk groups.

Registration: This study has been compiled based on the PRISMA checklist, and its protocol was registered on the PROSPERO (ID: CRD42024544037) and Research Registry (UIN: reviewregistry1829) website.

Implication for health policy/practice/research/medical education:

Our systematic review and meta-analysis showed that, high triglyceride-glucose index increases the risk of chronic kidney disease.

Please cite this paper as: Muhussin Ali M, Muslim Mhaibes R, Abdul-Mounther Othman M, R. Lahhob Q, Jasim Qasim M. Association between triglyceride-glucose index and risk of chronic kidney disease: a systematic review and meta-analysis. J Nephropharmacol. 2024;13(2):e12692. DOI: 10.34172/npj.2024.12692.

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