Submitted: 27 Apr 2024
Accepted: 07 Jun 2024
ePublished: 29 Jun 2024
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J Nephropharmacol. 2024;13(2): e12694.
doi: 10.34172/npj.2024.12694
  Abstract View: 123
  PDF Download: 91

Mini Review

Antioxidant therapy for hypertension; a mini-review on the recent findings

Samira Mehrabi Pari ORCID logo, Mohammad Memarian ORCID logo, Rahimeh Eskandarian* ORCID logo

1 Clinical Research Development Unit, Kowsar Educational, Research and Therapeutic Hospital, Semnan University of Medical Sciences, Semnan, Iran
*Corresponding Author: Rahime Eskandarian, Email: rheskandarian@yahoo.com


Oxidative stress is a key mechanism underlying hypertension. Therefore, antioxidant therapy is an attractive concept for hypertension. Antioxidant therapy has been shown to have a significant impact on blood pressure reduction in various studies. The duration of treatment before observing results can vary depending on the specific antioxidant used, the dosage, and the individual’s health status. Antioxidant therapy by reducing oxidative stress and improving endothelial function reduces the high blood pressure. Antioxidants may achieve their antihypertensive effects by reducing the formation of advanced glycation end products and aldehydes that impair vascular function and improving insulin resistance and endothelial function and also by normalizing calcium channels and peripheral vascular resistance.

Implication for health policy/practice/research/medical education:

Antioxidant therapy leads to reduce oxidative stress, leads to the improvement of endothelial function, and decreasing superoxide production and renal dysfunction and also cardiac damage.

Please cite this paper as: Mehrabi Pari S, Memarian M, Eskandarian R. Antioxidant therapy for hypertension; a mini-review on the recent findings. J Nephropharmacol. 2024;13(2):e12694. DOI: 10.34172/npj.2024.12694.

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