Saeed Hoseininia
, Sousan Mohammadi Kebar
* 1 Department of Internal Medicine, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Abstract
Bone marrow transplantation (BMT) can lead to renal manifestations, including acute kidney injury (AKI) and long-term renal dysfunction. Late-onset kidney disturbance can detect in around 20% of the BMT survivors. This condition is defined as bone marrow transplant nephropathy (BMTN). Total body irradiation is a main parameter in this syndrome, though concurrent or previous chemotherapies may aggravate the effect of radiation on the renal function and structure. BMT is characterized by inappropriate azotemia, anemia and hypertension while renal function may deteriorate acutely or more slowly. Other renal manifestations of BMT include hemolytic-uremia-like syndrome, which may manifest later (3-6 months or more), and membranous nephropathy, which is a rare complication of BMT.
Implication for health policy/practice/research/medical education:
Bone marrow transplant is a life-saving procedure for various hematological malignancies and non-malignant disorders. However, one of the significant complications associated with BMT is bone marrow transplant nephropathy, which can lead to significant morbidity and mortality.
Please cite this paper as: Hoseininia S, Mohammadi Kebar S. Renal dysfunction after hematopoietic cell transplantation; a mini-review study. J Nephropharmacol. 2025;14(1):e12695. DOI: 10.34172/npj.2024.12695.