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Submitted: 14 Feb 2017
Accepted: 23 Apr 2017
ePublished: 02 May 2017
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J Nephropharmacol. 2017;6(2): 110-113.
doi: 10.15171/npj.2017.14
  Abstract View: 10177
  PDF Download: 4774
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Original

Albuminuria in patients with young onset type 2 diabetes

Yassamine Bentata 1,2*, Redouane Abouqal 3,4

1 Department of Nephrology, Medical School of Oujda, University Mohammed the First, Oujda, Morocco
2 Laboratory of Epidemiology, Clinical Research and Public Health, Medical School, University Mohammed The First, Oujda, Morocco
3 Medical Emergency Department, Ibn Sina University Hospital, Rabat, Morocco
4 Laboratory of Biostatistics, Clinical and Epidemiological Research, Medical School, University Mohamed V, Rabat, Morocco
*Corresponding Author: *Corresponding author: Yassamine Bentata MD, PhD, , Email: bentatayassamine@yahoo.fr

Abstract

Introduction: Findings from several studies have indicated that patients with young onset diabetes (YOD) are more likely than those with late-onset diabetes (LOD) to have poor metabolic control and more diabetes-associated complications.

Objectives: This study was to assess assess the profile at admission and the evolution in a cohort of young patients presenting type 2 diabetes (T2D) and to study the influence of glycemic control on progression of albuminuria.

Patients and Methods: This is a prospective study. Inclusion criteria targeted patients who had T2D diagnosed before the age of 40 years and had been regularly followed in nephrology consultation for at least 36 months.

Results: A total of 121 patients met the inclusion criteria. Mean age at diabetes diagnosis was 39 ± 3 years and 64.5% were female. Mean body mass index (BMI) was 28.02 ± 4.47 kg/m2. 22.3%, 57.9% and 19.8% had respectively, negative, micro- and macro-albuminuria. 22.3% were hypertensive, 36.4% had controlled diabetes and 14.9% had an estimated glomerular filtration rate (GFR) of <60 mL/min/m2. At the end of follow-up, 27.3% were hypertensive, 24% had controlled diabetes, 27.3% had negative albuminuria, 17.4% showed rapid renal progression and cardiovascular events occurred in 12.4% of cases.

Conclusion: Control of blood pressure, glycemia and albuminuria remain difficult to achieve in adults with YOD type 2, thus exacerbating the renal and cardiovascular disease (CVD) risk


Implication for health policy/practice/research/medical education:

Patients diagnosed with type 2 diabetes (T2D) under the age of 40 years are designated as having young onset diabetes (YOD) and its prevalence is increasing. They are more likely than those with late-onset diabetes (LOD) to have poor metabolic control and more diabetes-associated complications.

Please cite this paper as: Bentata Y, Abouqal R. Albuminuria in patients with young onset type 2 diabetes. J Nephropharmacol. 2017;6(2):110-113. DOI: 10.15171/npj.2017.14.

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