Banafsheh Yalameha
* 
1 Department of Biochemistry, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
Abstract
Atherosclerosis is a chronic inflammatory disease occurring in arterial wall over many decades,
often leading to acute cardiovascular event. The different mechanisms are involved in the
development of this disease. Oxidative stress process is recognized as an important factor for
initiation and progression of atherosclerosis. Many therapeutic approaches exist for controlling,
preventing, and treating the disease. Antioxidants are the main compounds that inhibit oxidative
stress by oxidation of radical free and including protective effect against cardiovascular disease
like atherosclerosis. Recently, several drugs about novel perspectives have been discovered which
can improve lipid profiles. This review outlines the anti-atherosclerotic property of antioxidants
in prevention and improvement atherosclerosis and its new hopes.
Implication for health policy/practice/research/medical education:
Antioxidant therapy can be useful in improving and treatment of atherosclerosis while further research on the issue is still
required to extend our knowledge.
Please cite this paper as: Yalameha B. Antioxidant therapy to improve or resolve atherosclerosis; new hopes and current trends.
J Nephropharmacol. 2019;8(2):e05. DOI: 10.15171/npj.2019.18