Masoumeh Asgharpour
1* 
, Audrey Tolouian
2 , Lakkakula VKS Bhaskar
3 , Ramin Tolouian
4 , Nilofar Massoudi
5 1 Department of Nephrology, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
2 School of Nursing, University of Texas at El Paso, El Paso, TX, USA
3 Department of Zoology, Guru Ghasidas University, Bilaspur, 495009 (CG), India
4 Division of Nephrology, College of Medicine, University of Arizona, Tucson, Arizona, USA
5 Critical Care Quality Improvement Research Center at Shahid Modarres Hospital, Department of Anesthesiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract
Renal ischemia-reperfusion (RIR) is a pathological condition due to transient restriction of blood flow to the kidneys, which is followed by the subsequent recovery of perfusion and re-oxygenation. RIR injury contributes to the progression of renal dysfunction including acute kidney injury (AKI) in native and renal allograft transplant. The generation of reactive oxygen species (ROS) during oxidative stress contributes to the occurrence of RIR. Hence, the use of antioxidant compounds can improve oxidative stress due to RIR. This review highlights herbal antioxidant efficacy against RIR injury. The findings of this study indicate that antioxidant compounds with herbal origin could reduce complications due to oxidative stress related to RIR through diminishing lipid peroxidation, decreased production of malondialdehyde (MDA), apoptosis and increasing antioxidant enzymes activity. Reducing oxidative stress with the pharmacological approach of antioxidants can be a desirable target for ameliorating RIR.
Implication for health policy/practice/research/medical education:
Antioxidants diminish the oxidative damage caused by renal ischemia-reperfusion (RIR) through inhibiting the lipid peroxidation and increasing the activity of antioxidant enzymes. Hence, targeting the oxidative stress pathway with antioxidants can be a pharmacological approach to ameliorate RIR injury.
Please cite this paper as: Asgharpour M, Tolouian A, Bhaskar LVKS, Tolouian R, Massoudi N. Herbal antioxidants and renal ischemic-reperfusion injury; an updated review. J Nephropharmacol. 2021:10(1):e03. DOI: 10.34172/npj.2021.03.