Fatemeh Kharazmi
1 
, Hajaralsadat Hosseini Dastgerdi
1 , Shadan Saberi
2 , Maryam Maleki
3 , Nepton Soltani
1 , Mehdi Nematbakhsh
1,3,4* 1 Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
2 Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
3 Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
4 Isfahan MN Institute of Basic and Applied Sciences Research, Isfahan, Iran
Abstract
Sex hormones affect the developmental process and play important roles in the kidney’s structure and functions. Clinical and experimental results have indicated that kidney functions are different between the genders, and they may be associated with the sex hormones, which regulate the expression and action of transporters in the nephron. In the current short review, the data banks including PubMed, Google Scholar, and Scopus were reviewed to achieve the published related articles regarding the role of gender and diabetes mellitus in glucose transport in renal system.
Implication for health policy/practice/research/medical education:
It seems that the co-transporters of sodium-glucose (SGLTs) function is gender related, and to use SGLTs inhibitors as therapeutic agents in diabetic condition, the role of sex needs to be more specified.
Please cite this paper as: Kharazmi F, Hosseini Dastgerdi H, Saberi S, Maleki M, Soltani N, Nematbakhsh M. Glucose transporters in kidney; the role of gender and diabetes mellitus . J Nephropharmacol. 2022;11(1):e03. DOI: 10.34172/npj.2022.03.