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Submitted: 15 Mar 2021
Accepted: 16 Jun 2021
ePublished: 07 Jul 2021
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J Nephropharmacol. 2022;11(1): e6-e6.
doi: 10.34172/npj.2022.06
  Abstract View: 234
  PDF Download: 78

Original

Examination the antioxidant potentials and antidiabetic properties of phenolic extracts of some Iranian honeys

Mahmoodreza Moein 1,2, Soheila Moein 1,3 * ORCID logo, Fatemeh Farmani 1 ORCID logo, Sahere Rozbehan 3 ORCID logo, Zahra Sabahi 1 ORCID logo

1 Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Fars, Iran
2 Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Fars, Iran
3 Department of Biochemistry, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Hormozgan, Iran
*Corresponding author: Soheila Moein, Email: soheila_9@yahoo.com, Smoein@hums.ac.ir

Abstract

Introduction: In most ancient cultures, honey has been used for both nutritional and medical purposes.

Objectives: In this research, phenolic extracts of four Iranian honeys were evaluated to determine the antioxidant potentials using DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, nitric oxide (NO) radical scavenging and reducing power by ferric reducing activity of plasma (FRAP) method. Additionally, anti-diabetic properties of honey and phenolic extracts were evaluated by determination of α-amylase and α-glucosidase inhibition.

Patients and Methods: Besides, reducing potential was evaluated by ferric-reducing antioxidant power method. Moreover, determination of phenolic and flavonoid contents was performed. Moreover, inhibition of α-amylase and α-glucosidase of honey and phenolic extracts were evaluated.

Results: With considering to antioxidant potentials, Gavan (Astragalus) sample showed the greatest phenolic (3817±1.52 mg GAE/100 g), flavonoid contents (3.1±0.005 mg QE/100 g), and DPPH radical scavenging (IC50 = 2±0.003 mg/mL). Bahareh honey had the highest NO radical scavenging (IC50=0.0403±0.0009 mg/mL) and Meymand honey possessed the highest reducing potential by FRAP method (IC50=0.0018±0.000003 mg/mL). The maximum inhibition of α-glucosidase was shown in Meymand honey extract (46±0.1%). After sugar isolation, Zataria honey had the highest inhibition of α-glucosidase (54±0.6%) and the mode of α-amylase inhibition was noncompetitive by this honey. Whole extract (23±0.1%) and phenolic extract of Gavan honey presented the maximum inhibition of α-amylase (31.2±0.1%).

Conclusion: Honey samples showed antioxidant potentials and anti-diabetic properties by retardation of α-amylase and α-glucosidase.


Keywords: Antioxidant activity, α-Amylase inhibition, α-Glucosidase inhibition, Iranian honey, Radical scavenging

Implication for health policy/practice/research/medical education:

The samples of honey possessed antioxidant properties especially nitric oxide radical scavenging and anti-diabetic effects by inhibition of α-amylase, and α-glucosidase.

Please cite this paper as: Moein M, Moein S, Farmani F, Rozbehan S, Sabahi Z. Examination the antioxidant potentials and antidiabetic properties of phenolic extracts of some Iranian honeys. J Nephropharmacol. 2022;11(1):e06. DOI: 10.34172/ npj.2022.06.


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