Ramin Tolouian
1 
, Audrey Tolouian
2 , Farzaneh Dastan
3, Vida Farhangi
4 , Payam Peymani
, Sanam Saeifar
6 , Oscar Felipe Borja Montes
7 , Leila Mohmoodnia
8 , Mohammadreza Khosravifarsani
8* , Tella Sadighpour
9 1 Division of Nephrology, Southern Arizona VA Health Care system and University of Arizona, Tucson, Arizona, USA
2 College of Nursing, The University of Texas at El Paso, Texas, USA
3 Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Department of Medicine, Florida State University, Sarasota, Florida, USA
5 College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
6 Buchmann Institute for Molecular Life Sciences (BMLS), Cluster of Excellence Frankfurt Macromolecular Complexes (CEF-MC), Goethe University Frankfurt am Main, Frankfurt am Main, Germany
7 Department of Internal Medicine, University of New Mexico, New Mexico, USA
8 Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
9 American University of Antigua College of Medicine, Antigua and Barbuda
Abstract
Cisplatin is a first-line antitumor drug which is applied in the therapeutic field of numerous kinds of cancers. The main dose-dependent adverse effect of cisplatin is nephrotoxicity in approximately one-third of patients, who received this drug during their treatment. Oxidative stress is one of the most significant mechanisms in cisplatin nephrotoxicity. Cisplatin-induced oxidative stress stimulates apoptosis, inflammation, mitochondrial damage within cells, and endoplasmic reticulum (ER) stress. The administration of an antioxidant in this context could be a suitable approach for preventing of cisplatin nephrotoxicity. Antioxidants are categorized into four classes: dietary antioxidants, free radical scavengers, thiol-containing compounds, and iron chelators.
Implication for health policy/practice/research/medical education:
Cisplatin cytotoxicity is mediated by reactive oxygen species generation, reducing antioxidant enzymes and activation of apoptosis and inflammation pathways significantly.
Please cite this paper as: Tolouian R, Tolouian A, Dastan F, Farhangi V, Peymani P, Saeifar S, Borja Montes OF, Mohmoodnia L, Khosravifarsani M, Sadighpour T. Antioxidants and cisplatin nephrotoxicity; an updated review on current knowledge. J Nephropharmacol. 2023;12(1):e10556. DOI: 10.34172/npj.2022.10556.